Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China. Electronic address: liuchangqin@126.com. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA; Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA. Electronic address: bchol@uw.edu. Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: mshi70@uw.edu. Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: ginghina@uw.edu. Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA. Electronic address: cain@uw.edu. Department of Neurology, Center for Human Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: peggy.auinger@chet.rochester.edu. Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: zhangj@uw.edu.